Content

Slimming drugs are prescribed in combination with diet and exercise. In many cases, such therapy does not give positive results, then they resort to the help of potent substances. One of them is Sibutramine. The drug is used for obesity to reduce weight, which threatens the patient's health.

Sibutramine mechanism of action

The substance belongs to the group of appetite regulators. Sibutramine is a white or cream-colored crystalline powder. Release form - capsules for oral administration. The mechanism of action of the main substance is based on the rapid satisfaction of hunger, activation of the feeling of satiety. This leads to a decrease in food intake without effort on the part of the patient. Initially, Sibutramine was developed as a means to correct the psychoemotional state, and not to reduce body weight.

The process of absorption of food refers to the stimulators of signal transmission between neurons in the brain. There is a release of serotonin and norepinephrine into the intercellular space (synapse). Sibutramine blocks the reverse signal, due to which the concentration of neurotransmitters in the synapse increases. The signal of saturation is sent to postsynaptic cells more actively, and the body does not require additional nutrition.

The active substance molecules stimulate thermogenesis - the production of heat energy. As a result, the metabolism is accelerated, secondary and primary amines are formed, independently inhibiting the reuptake of norepinephrine, serotonin and the pleasure hormone dopamine. These processes stimulate rapid satiety, the feeling becomes permanent. The desire to snack disappears, the amount of food is significantly reduced, and the weight begins to go away.

The decrease in body fat with the use of capsules is complemented by an increase in high density lipoprotein levels. At the same time, there is a decrease in the amount of triglycerides, cholesterol, uric acid. Presumably, Sibutramine is not a mutagen, does not reduce fertility, does not have a carcinogenic effect. The substance reaches its maximum concentration in plasma in 1-2 hours. Sibutramine is excreted through the kidneys, the half-life is 16 hours.

Indications for use

Sibutramine medicines are highly potent medicines. You must understand that self-medication is strictly prohibited. It is important to take Sibutramine only after consulting a specialist. The course of treatment should be under the supervision of a physician. Indications for the use of the drug are conditions:

• Primary food obesity, in which the body mass index is more than 30–35 kg / m². An important condition for the appointment is the ineffectiveness of other methods of treatment.
• Insulin-dependent diabetes (type 2) with a body mass index of 27 kg / m² or more.
• Dyslipoproteinemia is a metabolic pathology characterized by a violation of the quantitative and qualitative parameters of plasma lipoproteins.

Contraindications

The medicine has a large list of contraindications. They are the following states:

• secondary obesity for organic reasons (diseases of the endocrine system, central nervous system);
• eating disorders (anorexia, bulimia);
• toxic goiter;
• violation of blood flow in the parts of the brain, peripheral vessels;
• generalized teak (Tourette's cider);
• heart disease (ischemia, arrhythmia, stroke, congenital heart disease);
• severe pathologies of the kidneys, liver;
• allergy to an active substance;
• pathology of the psyche;
• arterial hypertension (increased pressure);
• hormonally active tumor of the adrenal gland or other localization (pheochromocytoma);
• prostate adenoma;
• decrease or complete absence of the enzyme lactase (hypolactasia);
• angle-closure glaucoma;
• pregnancy and the period of breastfeeding;
• alcoholic, drug, pharmaceutical addiction.

There is a list of diseases in which diet pills with sibutramine are prescribed with extreme caution. These are the states:

• age under 18 and over 65;
• epilepsy;
• hypertension;
• coronary insufficiency;
• cholelithiasis;
• muscle spasms;
• hemorrhage (pathological hemorrhage in various parts of the body);
• blood clotting disorders;
• high blood levels of magnesium, potassium;
• dysfunction of the kidneys or liver.

Side effects

The studies have revealed the risk of adverse events when taking the drug. Side effects include:

• headache;
• dry mouth, nausea;
• anxiety, insomnia, acute psychosis;
• sweating, cramps;
• anorexia;
• constipation, hemorrhoids;
• overflow of blood vessels (hyperemia);
• increased bleeding due to a decrease in the number of platelets (thrombocytopenia);
• increased blood pressure;
• increased heart rate, tachycardia;
• loss of appetite;
• jade, purple;
• increased activity of liver enzymes.

Mode of application

Sibutramine tablets and capsules should be taken on an empty stomach. It is better to do this in the morning, before breakfast. You must drink 1 capsule. The instructions indicate that the daily dose of the medication is 10 mg. If the weight decreases slowly (less than 2 kg in 30 days), it is allowed to increase the drug intake to 15 mg per day. The ineffectiveness of the maximum dosage leads to the cancellation of the drug. If the patient's body response to treatment is inadequate (less than 5% body weight loss in 90 days), the medicine should not be taken for more than 3 months.

The appearance of side effects, poor tolerance of the components of the drug does not mean the immediate cancellation of Sibutramine. Its dosage is reduced to a minimum level of 5 mg. Deterioration in the patient's health indicates the need to end therapy. The course of treatment can last up to 12 months. This is the maximum duration of the drug.

special instructions

Reactions to the withdrawal of Sibutramine are rare. The use of the drug is justified if the result of the treatment of obesity is a weight loss of 5 kg or less in 3 months. It is recommended to correct nutrition, increase physical activity, and maintain a healthy lifestyle. All this will enhance the pharmacodynamic effect of sibutramine. Particular attention should be paid to your condition, to monitor the appearance of pain in the sternum, edema, progressive shortness of breath.

Taking Sibutramine for weight loss requires constant monitoring of heart rate and blood pressure. If its indicators exceed the value of 145/90 mm Hg, then the treatment should be stopped. It is strictly forbidden to combine the intake of capsules with alcohol, because it enhances the effect of the drug. This increases the risk of side effects, cases of overdose.

Drug interactions

1. Selective serotonin reuptake inhibitors (citalopram, fluoxetine, sertraline, paroxetine), opioids, antitussives, ergot alkaloids - the risk of serotonin syndrome increases.
2. Isoenzyme inhibitors (erythromycin, ketoconazole, cyclosporine, troleandomycin) - the QT interval may increase due to an increase in the concentration of sibutramine in the blood.
3. Macrolide antibiotics, dexamethasone, phenobarbital, rifampicin, phenytoin, carbamazepine - the risk of accelerating the metabolism of sibutramine increases.

Sibutramine preparations

Diet pills with sibutramine as a dietary supplement are commercially available. As a medicine, these drugs are available only by prescription. Examples of fat burners and supplements containing sibutramine hydrochloride monohydrate:

Name	Description	Features:
Reduksin	It is used for alimentary obesity	Many side effects
Goldline	Indian remedy for overweight therapy	Addictive with long-term use
	Accelerates lipid metabolism	Eliminates food addiction
	It is prescribed in cases where excess weight threatens the patient's life	Requires a long reception
Sibutrex	Suppresses the feeling of hunger	A large list of contraindications
	Overweight treatment	The appearance of constant thirst
Reductil	Enhances feelings of fullness	Sold online only
Lindax	Anoretical remedy for food obesity	Not used as a dietary supplement, only as a medicine

Sibutramine price

Russian pharmacists dispense sibutramine tablets only by prescription. The drug is banned for use in a number of developed countries of the world. There are many dietary supplements that contain the active ingredient sibutramine, but this is not indicated on the package. Such funds are positioned as food additives, although they have a psychotropic effect on the body.

The cost of Sibutramine is too high due to its inaccessibility. Foreign counterparts are expensive due to transportation costs. Most of the medicine is purchased through an online pharmacy or a supplement store. Price range in Moscow:

Name of place of purchase	Cost, rubles For 30/60/90 capsules
Reduxin pharmacy
Jiggy Jig online pharmacy for adults
Euro Pharma
Online Steroid Pharmacy
FitFarma
ZdravCity
Avicenna Pharma

Video

According to statistics, people who are very overweight often resort to pharmacology to reduce it. The top of the most popular weight loss drugs includes Sibutramine. According to the manufacturer's instructions, in terms of the spectrum of effects, it is anorexigenic, its use reduces appetite and cravings for food.

The initial development of Sibutramine was carried out in the field of psychology. Its use has been suggested as an antidepressant. However, during testing of the drug, an excellent anorexigenic effect was found. Subsequently, it began to be prescribed for the treatment of obesity of varying degrees.

The medicine is available in the form of capsules for oral use. They contain a light crystalline powder that can range from white to cream in color.

The active substance is sibutramine hydrochloride monohydrate. It was this that served as the name of the drug. On contact with water, the active ingredient dissolves, but this process proceeds most optimally at an acidity of 5.2.

Pharmacological properties

According to the spectrum of pharmacological effects on the body, Sibutramine belongs to an anorexigenic prodrug - a group of appetite regulators. To start the process of reuptake of neurotransmitters (serotonin and norepinephrine), it must break down into active metabolites (amines of the first and second order).

As a result of the synergism of the serotonergic and noradrenergic systems, the following pharmacological effects occur:

• growth of thermogenesis (an increase in the production of heat by the body occurs due to the activation of beta-3-adrenergic receptors);
• increased feeling of satiety, thereby reducing the amount of food consumed;
• affects brown adipose tissue, which is the most difficult to break down.

The result of losing weight occurs due to the simultaneous influence of the three specified factors. A decrease in appetite does not lead to the fact that the body begins to store reserves in the form of fat, as it usually does.

A similar reaction algorithm arises due to the fact that a person needs to maintain a constant temperature, and splitting fats serve as the main source of heating.

Due to the fact that Sibutramine increases the production of heat by the body itself, the receptors do not see the need to replenish the fat layer. Thus, there is a gradual adaptation to new fat parameters. The achieved result remains stable after discontinuation of the drug, provided that the PP regimen is observed.

Studies of the drug have revealed its ability to block the reuptake of dopamine, the hormone of pleasure, as well as to change the function of platelets. However, this effect is 3 times weaker than the effect on norepinephrine and serotonin.

The instructions for use of Sibutramine indicate that it:

• does not affect the release of monamines;
• does not affect the activity of MAO inhibitors;
• has no antihistamine effect;
• does not cause a decrease in cholinergic activity;
• does not interact with neurotransmitter receptors.

In view of this, in the absence of contraindications for admission, compliance with dosages and recommendations of a specialist, Sibutramine in the Russian Federation is approved for use.

Pharmacodynamics and pharmacokinetics

In the process of using the drug in the patient's blood, a change in the qualitative composition of the blood is observed.

In particular, there is:

• an increase in the concentration of high density lipoproteins and a decrease in low density lipoproteins;
• decrease in the proportion of triglycerides;
• reducing the amount of total cholesterol and uric acid.

Studies have shown that during therapy there is an insignificant increase in blood pressure (up to 3 mm Hg) and heart rate (up to 7 beats per minute). This is the main reason for the prohibition of the drug for patients with heart problems.

Passing through the liver, the drug breaks down into 2 components (mono- and didesmethylsibutramine). The drug is characterized by a relatively high bioavailability. The absorption of active ingredients is 77%, protein binding is 97%.

The maximum concentration of sibutramine in the blood is observed after 1-2 hours, and its decay products - after 3-4 hours. However, simultaneous consumption with food prolongs this period by an average of 30%.

Metabolized in liver cells. The half-life of sibutramine is about 1 hour. Its decay products - metabolites begin to be excreted from the body within 14-16 hours. Moreover, the excretion of inactive metabolites occurs through the production of kidneys, and sibutramine and active substances through bile.

Indications for use

Sibutramine, the instructions for the use of which have many contraindications, is not prescribed for all patients to lose weight.

An indication for use may be:

In all milder cases, experts advise against using Sibutramine due to the large number of contraindications and side effects.

Contraindications

Sibutramine, the instructions for the use of which indicate the seriousness of its effect on the human body, is dangerous to use for most patients.

In addition, there are strict restrictions on compatibility with other medications affecting the central nervous system. The parallel use of not only monoamine oxidase inhibitors, antipsychotics, sedatives, other pharmacological agents for weight loss and L-tryptophan is prohibited.

Their reception is possible only 2 weeks after the cessation of therapy with the use of Sibutramine.

At what age can the drug be used

Sibutramine, the instructions for the use of which have strict age restrictions, is allowed for admission only to persons who have reached the age of 18 (only in the absence of contraindications). The lower threshold is 65 years of age, after reaching it, the use of the drug will cause serious harm to health.

Instructions for use, dosage of the drug Sibutramine

The established medical practice is such that this drug is prescribed only in the most extreme cases, when other methods of getting rid of excess fat did not give the desired effect. A specialist with medical education and experience in weight correction has the right to appoint him.

After the start of taking Sibutramine, it is necessary to maintain strict control of blood pressure and heart rate.

The minimum frequency of inspections should be 2 weeks in the first two months. Then their number can be reduced to 1 time in 30 days. When significant pressure surges or arrhythmias are detected, the frequency of checks increases. If the values \u200b\u200bof these indicators reach the limiting limits (140/90 mm Hg), Sibutramine is discontinued.

The medicine is taken once a day. The optimal time for this is morning. Allowed to be consumed both on an empty stomach and after breakfast. The drug must enter the stomach in a complete shell, so it is prohibited to open or chew it.

To facilitate swallowing, the capsule is washed down with water. The standard dosage is 10 mg. In the case of mild side effects, it is halved.

In the absence of the desired effect within 1 month, the dosage is increased to 15 mg. The total duration of therapy for most cases is 1 year. However, in the case of taking higher dosages, the duration of Sibutramine use is adjusted. The use of the drug does not in any way preclude physical activity.

Side effects

According to statistics, every 9 out of 100 patients is faced with the downside of taking a drug to reduce appetite. Possible negative reactions arise from the cardiovascular, nervous, digestive and genitourinary systems, as well as the musculoskeletal system, ENT organs and skin.

List of possible side effects:

The presence of at least one of the above symptoms is a good reason for adjusting the treatment of obesity. The doctor, based on the general condition of the patient, can reduce the dosage of Sibutramine or completely cancel it.

Overdose

Sibutramine, the instructions for the use of which contains a clear description of the regimen, belongs to the number of medicines, an overdose of them can lead to the most serious consequences, up to and including death.

It manifests itself in a multiple increase in side effects. If, for any reason, the required dose has been exceeded, it is necessary to contact the nearest medical institution for rehabilitation therapy.

Along with the intake of sorbents, it includes:

• symptomatic therapy;
• the introduction of beta-blockers (with increased pressure and arrhythmias);
• monitoring the functioning of vital organs.

Self-rehabilitation at home in case of an overdose with Sibutramine is unacceptable.

special instructions

The use of the drug is possible only under the supervision of a doctor and must necessarily be supplemented with comprehensive weight loss measures.

The number of mandatory parallel measures include the transition to a proper diet, lifestyle changes, giving up bad habits, engaging in light aerobic activity. In some cases, dieting is required to treat obesity.

Drug interactions

Parallel use of Sibutramine with other drugs is possible only after obtaining permission from the attending physician.

Among the features of drug interactions, it is worth noting:

• antioxidants such as erythromycin, cyclosporine and ketoconazole slow down the elimination of Sibutramine from the blood, thereby increasing its concentration;
• drugs characterized by a serotonergic effect (Fevarin, Paroxetine, Efectin, Citalopram) can cause convulsions, diarrhea, fever and serotonin intoxication, which can lead to death;
• ephedrine and pseudoephedrine drugs in combination with Sibutramine increase blood pressure and pulse;
• antibiotic agents of the macrolide group help accelerate the absorption of Sibutramine.

Simultaneous use of alcohol with the drug does not change the effect of the drug on the body. However, this practice is not conducive to weight loss.

Analogs

Despite its many side effects, Sibutramine is one of the top weight loss drugs. There are a number of drugs on the market with identical active ingredients.

Examples of analogues:

Slimia, Lindaxa and Meridia are products of foreign pharmaceutical companies. In view of the policy pursued abroad in relation to Sibutramine, they ceased to be produced.

For reference, sibutramine hydrochloride monohydrate is banned in the United States, EU countries, China, Australia, Canada, Mexico, India, New Zealand, and Hong Kong. In Russia, it is still among the allowed, but it is sold only by prescription.

Terms, conditions of sale and storage

Due to the peculiarities of the effect of the drug on humans, its purchase in pharmacies is possible only with a prescription. It must be printed on a special form and have all the necessary seals and signatures.

The shelf life of Sibutramine is 2 years from the date of production. It is always indicated on the outer packaging and blister. Storage advice is the same as for any medicine - dark, cool place out of reach of children. Ideal conditions for placing the drug are on the top shelf of the refrigerator.

Price in pharmacies in Moscow, St. Petersburg, regions

The cost of the drug depends on the volume of the package. In a dosage of 20 mg, Sibutramine is available in 50 or 64 tablets in one carton box. And the 15 milligram version is sold in 30 or 100 pieces. in a plastic container or in a mini-format for 10 capsules. The higher the dosage and size of the package, the more expensive the purchase will be.

The average cost of 50 capsules of 20 mg of a drug in the capital is 2,990 rubles. In St. Petersburg, even in online pharmacies, it is quite problematic to find it. The purchase of Sibutramine (the same 50 capsules of 20 mg each) in the city on the Neva will cost almost twice as much as 4,820 rubles.

The average price spread for a drug is shown in the figure:

The cheapest drug can be bought in Moscow. For residents of the Far East, it will cost half as much, which is quite explainable by transport costs.

Despite the fact that there is a noticeable price variation among sellers of this drug on the Internet, you need to make a purchase only in trusted places. This will minimize the likelihood of getting fake.

Despite the obvious effectiveness of Sibutramine in the fight against obesity, its use outside the instructions for use and without a doctor's prescription is fraught with serious health problems. It is not for nothing that the drug was banned in leading countries back in the 2000s, when patients began to arrive with complaints of pain in the heart, pressure surges and nervous disorders.

Article design: Mila Friedan

Video about Sibutramine

Review of taking Sibutramine:

Many people looking to lose weight know that it is not easy to do this. After all, you need to have tremendous willpower to follow a diet. And after you have managed to lose those extra pounds, you need to moderate your appetite in every possible way so that you do not return at a double speed. Very often, those who want to lose weight resort to the help of medications. These drugs, at least many of them, contain a chemical called sibutramine. It is about him that will be discussed in this article.

What is Sibutramine?

If several attempts to lose weight do not bring any results and many effective methods have already been used to lose excess weight, people have a significant decrease in self-esteem in this regard. And this can serve as a starting point in the development of deep psychological complexes and severe depression. Perhaps that is why many losing weight believe that it is possible to lose extra pounds with the use of drugs, for example, such a drug as Sibutramine. What is it? An unconditional good that will eradicate the root of evil, or a time bomb that can finally undermine human health?

It is important to understand that Sibutramine is a potent medical preparation, not a substance harmless in its composition. And therefore, like any medicine, it has some contraindications, side effects and has negative effects on the body.

In this regard, it is necessary, before starting to take this drug, to consult with your doctor about the use of this medication. But after all, people really lost weight, taking "Sibutramine", the reviews of those losing weight in every way confirm this, you say. But at what cost did it happen and what side effects did they have after taking Sibutramine? This article will try to answer these and other questions.

Description

It is a centrally acting drug for the adjuvant treatment of obesity. It must be used in conjunction with a strictly controlled diet and increased physical activity. After taking the drug "Sibutramine" (tablets or capsules), a feeling of fullness comes. That is, even a small portion of food makes a person feel full. And this leads to a decrease in food intake. By suppressing the reuptake of serotonin, the drug "Sibutramine" affects the center of the brain responsible for appetite.

special instructions

The use of the drug is possible only when all other measures aimed at weight loss are ineffective. Therefore, only in these exceptional cases it is necessary to use "Sibutramine". Losing weight reviews mainly contain information that energy increases. Therapy should be carried out under the strict supervision of a physician who has experience in correcting obesity as part of a comprehensive treatment, such as:

1. Diet.
2. Changing eating habits and lifestyle.
3. Increased physical activity.

Contraindications

As mentioned above, everything related to drugs causes side effects and is not always and not suitable for everyone for medical reasons. This also applies to such a drug as "Sibutramine". Instructions for the use of this medication have such an important point as contraindications. List of diseases in which the use of "Sibutramine" is prohibited:

1. Hypersensitivity of the body.
2. The presence of organic causes of obesity.
3. Mental illness.
4. hearts.
5. Heart failure.
6. Congenital heart defects.
7. Tachycardia.
8. Arrhythmia.
9. Stroke.
10. Cerebral circulation disorders.
11. Severe violations of liver and kidney function.
12. Drug and alcohol addiction.
13. Pregnancy.
14. Lactation period.
15. Glaucoma, etc.

Side effects

Reading numerous reviews, especially those that describe side effects after taking this drug, one involuntarily thinks that many simply write off their sores on this drug. After all, even a simple and well-known "Analgin" causes practically similar phenomena after its adoption. It is still better, before taking "Sibutramine", reviews of doctors, side effects to study very carefully. Possible:

1. Headache and dizziness.
2. Insomnia.
3. Feelings of fear and excitement.
4. Blood pressure surges.
5. Tachycardia.
6. Arrhythmia.
7. Chills.
8. Stool problems.
9. Dry mouth.
10. Nausea and vomiting.
11. Sweating.
12. Changes in psyche and behavior.
13. The change
14. Back pain.
15. Allergic reactions.
16. Flu-like syndrome.
17. Urinary tract infections.
18. Laryngitis.
19. Increased cough.
20. Drug addiction effect.

Overdose

There are times when there is an increase in the severity of side effects. This can be when an overdose of a drug, including such as "Sibutramine", has occurred accidentally or on purpose. In this case, the doctors' comments agree that the patient needs:

1. Take activated carbon.
2. Call a doctor or medical aid.
3. Contact the nearest Poison Control Center.

Application

How to use this powerful slimming agent called Sibutramine? Instructions for use quite easily explains what the daily intake of this medication is. The initial dose of the drug per day is 10 mg. The capsules are taken in the morning. It is necessary, without chewing, to drink plenty of water (at least 250 ml) of the Sibutramine tablets. Instructions for use (the base of tablets is described in this manual) will help you use the product correctly.

If the effect is not observed at such a dosage (a decrease in body weight within 4 weeks - 2 kg), then with good tolerability of the drug, the rate can be increased to 15 mg per day. If no positive dynamics is observed, the use of "Sibutramine" should be discontinued. The period of taking the drug at a dose of 15 mg is limited in time.

It is necessary to take "Sibutramine" (tablets) within 1 year. It is not recommended to use it longer, as there is no data on the effectiveness and safety of a longer course of taking the medication. If the patient fails to lose at least 5% of the total weight within 3 months, then the drug intake must be completed.

Regularly taking "Sibutramine", reviews of those losing weight confirm this information, patients manage to lose excess weight within 6 months. The result is maintained for the entire duration of the course of treatment. If the daily intake of the medicine was missed, then it is not recommended to double the dose the next day. It is necessary to return to the usual pill regimen. It is necessary to stop taking medications after consulting your doctor.

Precautions

It must be understood that the effect of the drug will be noticeable only in combination with diet. It is necessary to use the means for weight loss "Sibutramine", which was described in the previous section, with some caution. After all, some of its effects on the human body are already known.

It is also necessary to adhere to certain conditions for those people who use this medicine. These are the conditions and precautions that will not lead to unpleasant consequences if followed:

1. Elderly age of the patient.
2. Driving a car.
3. Working with mechanisms.
4. Simultaneous intake of medicine and alcoholic beverages. "Sibutramine" enhances the sedative effect of alcohol.

A drug Sibutramineused as an aid in the fight against obesity. The drug is used in conjunction with a carefully controlled diet and increased physical activity. Sibutramineindicated only in patients with a baseline body mass index (BMI) of at least 30 and in patients with a BMI greater than 27 and risk factors such as diabetes or high blood pressure.

Indications

By suppressing the reuptake of serotonin, sibutramineaffects the center in the brain that controls appetite.

Contraindications

Hypersensitivity, the presence of organic causes of obesity, neurotic anorexia, bulimia, mental illness, Tourette's syndrome, coronary heart disease, decompensated heart failure, congenital heart defects, occlusive peripheral arterial disease, tachycardia, arrhythmia, cerebrovascular diseases, hypertension, hypertension, hyperthyroidism or kidney, benign prostatic hyperplasia, pheochromocytoma, glaucoma, established pharmacological, drug and alcohol dependence, pregnancy, breastfeeding

Limitations

Epilepsy, motor-verbal tic (involuntary muscle contractions, impaired articulation), children and old age (safety and efficacy of use in children under 18 and in people over 65 have not been determined).

Method of administration and dosage

The initial dose is 10 mg (with poor tolerance, 5 mg may be taken); in case of insufficient effectiveness after 4 weeks. the dose is increased to 15 mg / day. Duration of treatment - 1 year
Beginning of action Sibutramine
A significant change in body weight is possible after a few weeks or months
Duration of action Sibutramine
With regular intake of sibutramine, most patients manage to lose weight within 6 months. The result persists as long as the treatment continues
If the appointment is missed
If you haven't taken your medicine within one day, do not double your dose the next day. Return to your usual regimen.
Termination of admission
Do not stop treatment without consulting your doctor

special instructions

Meridia and other appetite suppressants increase the risk of potentially dangerous cardiovascular and cardiopulmonary diseases. If you experience unusual or unpleasant reactions to the drug, stop taking sibutramineand see a doctor immediately.

Precautions

Elderly patients are prescribed the drug with caution.
Driving and operating machinery
Avoid these activities until you figure out how the medicine is working for you.
Sibutraminemay enhance the sedative effect of alcohol. Consult with a lie.

Overdose

Increased severity of side effects
Take activated charcoal and call a doctor, emergency room or nearest poison control center immediately

Drug interactions

Can't take sibutramineif you are taking monoamine oxidase inhibitors, other medicines for weight loss, depression medicines, migraine medicines, dihydroergotamine, meperidine, fentanyl, pentazocine, dextromethorphan (found in many cough suppressants), lithium, or tryptophan. Sibutramine can interact with ketoconazole, erythromycin, cough and cold medicines, allergy medications, and decongestants. Check with your doctor.

Side effects

There were no reports of serious side effects. However, if you develop symptoms that you did not have before taking the medication (such as shortness of breath, chest pain), see your doctor.
Possible dry mouth, constipation, insomnia
Sometimes accompanied by headaches, sweating, high blood pressure, and increased heart rate

Main settings

Name:	SIBUTRAMINE
ATX code:	A08AA10 -

Part of preparations

ATX:

A.08.A.A Centrally acting obesity drugs

A.08.A.A.10 Sibutramine

Pharmacodynamics:

Prodrug, pharmacological action due to metabolites that inhibit the reuptake of monoamines (norepinephrine and serotonin). By increasing the content of neurotransmitters in synapses, it activates central serotonin 5-HT receptors and adrenergic receptors. Suppresses appetite, which leads to a decrease in food intake. Increases thermogenesis. Due to the activation of β 3 -adrenergic receptors, metabolic processes in brown adipose tissue are accelerated. Sibutramine metabolites do not inhibit monoamine oxidase, do not affect the release of monoamines. It helps to reduce the content of total cholesterol, low density lipoproteins, triglycerides and uric acid, and also increases the amount of high density lipoproteins in the blood plasma.

Pharmacokinetics:

After oral administration, up to 77% is absorbed in the gastrointestinal tract. The maximum concentration in blood plasma is reached after 1.2 hours. It undergoes primary passage through the liver with the formation of two active metabolites: mono- and didesmethylsibutramine, the concentration of which in the blood reaches a maximum 3-4 hours after taking the drug.

The connection with plasma proteins is 97%, metabolites - 94%.

Metabolism in the liver: inactive metabolites are formed by hydroxylation and conjugation.

The half-life is 1.1 hours; monodesmethylsibutramine - 14 hours; didesmethylsibutramine - 16 hours. Elimination by the kidneys.

Indications:

It is used to treat obesity.

IV.E65-E68.E66.0 Obesity due to excess intake of energy resources

Contraindications:

Organic causes of obesity, anorexia nervosa, decompensated cardiovascular insufficiency, thyrotoxicosis, severe liver and kidney dysfunctions, advanced age over 65 years, individual intolerance.

Carefully:

Arrhythmia, anorexia nervosa, uncontrolled arterial hypertension, cholelithiasis, neurological disorders (convulsions).

Pregnancy and lactation: Method of administration and dosage:

Inside in the morning with meals or on an empty stomach 1 time / day. The initial dose is 10 mg. With poor tolerance - 5 mg.

Highest daily dose: 15 mg.

Higher single dose: 15 mg.

Side effects:

Central and peripheral nervous system: insomnia, paresthesias, emotional lability.

Cardiovascular system: tachycardia.

Digestive system: loss of appetite, constipation, sometimes exacerbation of hemorrhoids.

Allergic reactions.

Overdose:

Increased side effects.

Treatment is symptomatic.

Interaction:

The concentration of the drug in blood plasma is increased by inhibitors of the isoenzyme 3A4 of cytochrome P450: ketonazole,.

Drugs with serotonergic activity increase the risk of developing serotonin syndrome.

The control of the glycemic level decreases with the simultaneous use of the drug with thiazide diuretics, slow calcium channel blockers, lithium preparations, glucocorticoids, isoniazid, sympathomimetics, nicotinic acid, phenytoin, phenothiazines, thyroid hormones.

With simultaneous use with furosemide, it is necessary to reduce the dose of the drug.

Special instructions:

If there is no effect within 3 months - a decrease in body weight by 5% - the drug should be stopped.

Instructions