Instructions

If you have unprotected sex, go to the pharmacy. The sooner you take Postinor, the more effective the result will be. Keep in mind that the probability of a positive result within 24 hours after the act is 95%, after 48 hours the percentage drops to 85. If you take between 48 and 72 hours, you will avoid an unplanned one with a 58% chance. After 72 hours, taking the drug will not give any results. Therefore, to protect yourself from unwanted consequences, act quickly.

Purchase the medicine and read the instructions carefully. Take the first one immediately after sex or within 72 hours. Do not chew or crush it and drink it with a small amount of water. After 12 hours, take another tablet. If you experience vomiting or diarrhea within two hours of taking this medicine, take an extra tablet. The medicine can be taken on any day of the menstrual period.

Remember that Postinor should not be taken more often than once every four months. If you experience uterine bleeding after taking the pills, consult a doctor immediately. The drug is suitable for women with a regular menstrual cycle. If you do not have a regular cycle, consult your gynecologist before taking the medicine.

Postinor has a number of contraindications. The medicine contains a high concentration of hormones, therefore, it has side effects. If you take several tablets at once, your level of the progestin hormone will sharply increase, which will lead to heavy bleeding. Therefore, the drug should be taken strictly according to the instructions and after consultation with a doctor. Additional side effects include vomiting, diarrhea, dizziness, fatigue, dysmenorrhea, breast pain and menstrual irregularities.

If you have had problems with the liver or gall bladder, you are contraindicated to take the drug. The drug is not recommended for young girls, as taking it can cause serious hormonal imbalances in the body.

Keep in mind that when Postinor is used simultaneously with certain medications, its contraceptive effect is reduced. Do not take the medicine together with St. John's wort, griseofulvin, tetracycline, ampicillin, rifampicin, carbamazepine and barbiturates.

Video on the topic

note

Postinor does not affect the speed of attention and does not interfere with driving.

There are quite a few situations when it is necessary to use emergency contraception methods. This could be unprotected sexual intercourse, when the woman did not give her consent, or the usual situation with a torn condom, and much more. One of the most popular drugs that ladies use to correct the situation is Postinor. It is also a rather controversial remedy, according to reviews.

Without exaggeration, Postinor can be called one of the most discussed drugs in the world. Some claim that it is completely harmless and is great for preventing unwanted pregnancy. Others claim that the drug causes a whole hormonal storm in a woman’s body. But both of them are sure that if you have to take Postinor, you need to strictly follow the instructions.

What is Postinor and how does it work?

Postinor is a hormonal contraceptive that is usually taken after sexual intercourse in emergency cases. With its help, they prevent unwanted pregnancy if this was not taken care of in advance, for various reasons. According to the instructions, for such a drug to work, it must be taken as early as possible, the deadline is 48 hours after unsafe sexual intercourse.

It is a Postinor tablet that needs to be taken in 2 doses: the first after sexual intercourse, the second after 12 hours.

The combination of hormones in it, according to doctors, is lethal. That is why it is mostly not recommended for use. Some doctors even claim that such a drug can be used only in cases of dire necessity and only 2 times in a lifetime. Those who still take risks and decide to try such a drug should carefully read the instructions in order to clearly understand what can follow from taking such tablets.

Postinor temporarily stops the ovulation process and prevents the fertilization of the egg. In addition, it can cause the structure of the uterus, which is why, if conception occurs, a mini-abortion occurs.

Side effects include weakness, headache, nausea, spotting and much more. In addition, women have problems with their cycles.

Advantages and disadvantages

Among the advantages of this drug is a 100% result, i.e. pregnancy is guaranteed to occur. And this is, perhaps, its only advantage. There are many more disadvantages of such a contraceptive, so that one can evaluate whether the gamble was worth the candle.

The main active substance of this drug is the hormone levonorgestrel. The main complaint of doctors about the emergency contraceptive drug is that even after one dose it can negatively affect the activity of the entire reproductive sphere of a woman. Often, ladies who have already tried Postinor later cannot conceive due to ovarian dysfunction and cannot bear due to the development of ectopic pregnancies.
After taking Postinor, a woman is advised to visit her doctor to check if everything is okay. In addition, it is advisable to undergo a series of tests that will allow you to assess the damage caused to the lady’s genital area.

It is worth considering that this drug is completely banned in some countries. And it’s better to take care of contraception in advance, which will reliably protect you from various problems. By the way, it is worth considering that Postinor does not protect against sexually transmitted diseases.

"Postinor" is an emergency contraceptive that is used to prevent unwanted pregnancy after unprotected sexual intercourse. It can be used within 72 hours after intimacy.

Why is emergency contraception needed?

Emergency contraception is a way to avoid pregnancy if you accidentally have unprotected sex. The key word here is emergency. This means that contraceptive measures are taken as a result of unforeseen circumstances. To protect against pregnancy, these measures must be taken as quickly as possible and they must be sufficiently reliable. There are many reasons why unprotected sexual intercourse can occur. Fortunately, they do not occur so often. But one way or another it can happen to every woman, so it is better to always keep emergency contraceptive medications on hand. They cannot be used more often than once every six months, otherwise serious consequences for the body cannot be avoided. If the need for “fire measures” arises more often, it is better to reconsider your prevention strategy.

Medicines for emergency contraception

Drugs can be divided into two main groups. The first is products containing progestins (“Postinor”, ​​“Escapelle”). They should be applied as soon as possible after unprotected contact. If taken more than 72 hours later, they may not work. These drugs contain a significant dose of hormones, so after taking, nausea, headache, vomiting, diarrhea, breast engorgement and menstrual irregularities may occur. But overall, this is the most modern and fairly safe method of emergency contraception.

The second group is agents and progestins (combined). This includes conventional oral contraceptives, but they are taken in a much larger dose according to a specific regimen (Yuzpe method). The good thing about these products is that they are easily accessible and inexpensive. Naturally, they also have side effects - the same as with the usual use of estrogen-containing oral contraceptives.

If we evaluate the effectiveness of the above-described means, when used correctly, it approaches 85–90%.

What is the difference between emergency contraception and abortion?

Emergency contraceptives, including Postinor, are used to prevent pregnancy. In turn, abortion is the termination of an ongoing pregnancy by surgical or chemical means. Thus, from the moral and ethical side, the use of Postinor cannot be equated with an abortion, since at the stage when emergency contraceptives can be used, there is no embryo as such.

There is also a health factor. No one doubts that abortion can have an extremely negative impact on women's health. "Postinor" also cannot be called beneficial for women's health; its use can cause many side effects. This is a real hormonal shake-up for the body. However, when comparing the possible consequences, the use of emergency contraception seems preferable to abortion and from a medical point of view.

"Postinor" is currently one of the most popular drugs for preventing unwanted pregnancy. Among the female half of the population, due to its properties and characteristics of use, it received the name of a remedy that terminates pregnancy “the next morning.” In developed countries, Postinor is not used as a contraceptive; this drug is prescribed only after consultation with a specialist and is sold in pharmacies strictly according to a prescription due to the unsafety of its use. In our country, the drug can be bought freely at any pharmacy if it is available in the range, and if it is not available, you can place an order, and in the shortest possible time it will appear on the pharmacy counter. The drug is used as an emergency prevention of unwanted pregnancy; it is not used for continuous use. But some women have found Postinor to be used on an ongoing basis as a method of contraception.

The drug "Postinor" - pharmacological properties

The medicine has progestogenic, antiestrogenic and contraceptive properties, therefore, it works in three directions:

• blocks the release of an already mature egg from the ovary into the fallopian tubes, as a result of which fertilization by sperm does not occur;
• in the case of ovulation and fertilization, it prevents the fertilized egg from implanting into the walls of the uterus by changing the composition of the endometrium, as a result it becomes loose and the egg cannot attach to it;
• changes the composition of cervical mucus, as a result of which it becomes viscous, the speed of sperm decreases, they cannot penetrate the uterine cavity, therefore the process of fertilization does not occur.

If the fertilized egg does attach to the walls of the uterus, the drug becomes ineffective.

In what forms is the medicine available?

This drug is available in a single form - tablets. White or milky oval tablets. One tablet contains 0.75 mg of the active substance - levonorgestrel - an artificial hormone and other additional substances (silicon dioxide, magnesium stearate, talc, corn lactose monohydrate). One cardboard package contains one blister containing two tablets.

Indications for use of the drug

Accepted only in cases where sexual intercourse was forced and unprotected or when the condom was mechanically damaged in order to prevent unwanted pregnancy. It is not recommended to constantly take this drug, since its negative effect on the body leads to hormonal changes in the future and threatens infertility, which is difficult to treat.

The effectiveness of "Postinor"

The effectiveness of the drug is on average about 85% and depends on several factors, such as the correct use of the medicine and the time that has passed since sexual intercourse. If no more than 24 hours have passed since sexual intercourse, the effectiveness of the drug reaches 95%, if no more than 48 hours - 85%, if more than 48 hours and up to 72 hours - less than 58%.

Why is the drug dangerous?

Like all hormonal drugs, Postinor has a number of side effects. The most common:

• allergic reactions - rash, itching, Quincke's edema;
• general symptoms - chills, sweating, feeling hot, weakness, lethargy, pain in the lower abdomen;
• from the digestive system - nausea, vomiting, stool disorders (diarrhea);
• from the central nervous system - headache, dizziness, irritability;
• on the part of the reproductive system - intermenstrual bleeding, its pain, the appearance of discharge when pressing on the nipples, in girls who took Postinor, the delay of menstruation may be 5-7 days, there may also be amenorrhea - absence of menstruation, which in the future can lead to infertility ;
• hormonal disorders - male pattern hair growth (appearance of facial hair);
• violation of carbohydrate and fat metabolism (body weight can either decrease or increase);
• increasing the likelihood of developing an ectopic pregnancy.

Assessing the consequences of Postinor, many women leave negative reviews, because the drug must be taken very carefully.

How to take it?

Postinor is taken as soon as possible after unprotected sexual intercourse has occurred. During the first 48 hours, you should take one tablet of the drug orally, without chewing, with a small amount of water. 12 - 16 hours after taking the first tablet, you must take the second, but no later than 72 hours. If vomiting occurs, another tablet is taken within 2 - 3 hours after taking the medicine. "Postinor" can be used on any day of the menstrual cycle. If there is irregularity in the menstrual cycle, then before taking the drug it is necessary to exclude the presence of pregnancy. It is not advisable to take the drug more than once during one menstrual cycle. After taking Postinor, until the onset of menstruation, during sexual intercourse you should use barrier methods of contraception, such as a cervical cap or a condom.

What could be the threatening consequences of taking Postinor?

As a result of taking the drug, heavy uterine bleeding may develop as a result of an increase in the gestagen hormone in the blood and a change in the thickness of the endometrium. The occurrence of bleeding should serve as a signal to seek qualified medical help.

Another very dangerous side effect of the drug is increased blood clotting, which can result in thrombosis of blood vessels. The blockage can be partial - when the lumen of the vessels is not completely blocked, or complete. In this case, there is a high probability of developing ischemic stroke with various types of paralysis and paresis.

In some cases, the resulting blood clots can break off and result in a brain hemorrhage, sometimes fatal. The consequences of "Postinor", reviews from women indicate this, are very dangerous, so you should not take this drug lightly.

To whom is the drug contraindicated?

Termination of pregnancy with Postinor is contraindicated in a number of diseases and conditions of the body. The main ones:

• diseases of the liver and biliary tract with impaired functions (liver failure) due to the fact that hormone metabolism occurs in the liver;
• the age of girls under 16 years old - due to the negative impact on the development of the female hormonal system;
• pregnancy - due to a negative effect on the fetus;
• lactation period - due to the high probability of passage into breast milk and effects on the child;
• individual sensitivity to active and excipients;
• uterine bleeding of unknown origin - due to an increase in their duration;
• any infectious diseases of the genitourinary system (in particular, we are talking about genital herpes);
• disruption of the enzymatic activity of the gastrointestinal tract, when the process of absorption of glucose and galactose is disrupted;
• cancer of any organ - due to the likelihood of accelerated tumor growth and the appearance of metastases;
• disruption of the circulatory system, when there is a tendency to increased thrombus formation;
• Crohn's disease - due to a decrease in absorption and assimilation of the drug and, as a result, a decrease in the effectiveness of the drug;
• peptic ulcer of the stomach and duodenum - due to the high likelihood of gastric bleeding.

Features of the course of menstruation after "Postinor"

The course of menstruation, its very appearance, says a lot. With their appearance, we can conclude that there is a pregnancy. But this may also indicate some violations in this area. There are two possible options for menstrual irregularities after using the drug:

1. Menstruation after Postinor may be delayed for up to one week (in cases where more than two weeks have passed and menstruation has not started, you should immediately contact a gynecologist, as this may indicate pregnancy or be a consequence of the negative effect of the drug itself on the female body) , sometimes amenorrhea occurs - absence of menstruation, which leads to infertility;
2. Severe uterine bleeding, which is a signal to contact a medical facility.

For what menstrual cycle disorders should Postinor not be used?

There are a number of menstrual cycle disorders for which the drug is strictly not allowed to be used:

• heavy and prolonged periods;
• brown discharge instead of menstruation;
• bleeding from the uterine cavity;
• pain during menstruation;
• Irregular menstrual cycle.

"Postinor" price

The cost of the drug depends on which pharmacy or pharmacy chain it is sold at. For those wishing to purchase Postinor, the price ranges from 228 to 281 rubles per package with two 0.75 mg tablets. The cost of the drug may vary depending on the region where you purchase it. Also, the price differs among pharmacy chains. In general, the drug is one of the available medical products for different segments of the population.

Consequences of "Postinor" - reviews

Many women, despite the consequences of this drug, used it and continue to use it. There are different views on the use and consequences of Postinor. Reviews about this medication are mixed. Some claim that the artificial hormone really helps, others are not so sure. According to women's testimonies, Postinor, whose price is relatively low, is not always effective in preventing unwanted pregnancy. On the contrary, in some cases it can only strengthen it.

There is evidence that the drug can postpone menstruation. But this is not scientific information, so it is very unsafe to use it for these purposes. The consequences of "Postinor", reviews from women indicate this, may worsen as a result of failure to follow the instructions. Sometimes women, having a great fear of pregnancy, can take pills, forgetting about the rules of use. It’s worth “pulling yourself together,” focusing on your condition and trying to protect your health. May appear after Postinor. This is not an indicator that pregnancy has occurred; such a phenomenon may indicate the occurrence of side effects from the drug.

"Postinor", the use of which is not a panacea for pregnancy, affects the woman's health. To prevent pregnancy, you can use other methods of protection, such as a condom, then there will be no risk of side effects from the drug.

1 tablet contains 750 mcg , as well as colloidal anhydrous silicon dioxide, magnesium stearate, potato and corn starch, talc, lactose monohydrate.

Release form

Tablets packaged in blisters of 2 pcs. The package contains 1 blister.

Postinor contraceptive pills are flat, approximately 6 mm in diameter, chamfered, almost white in color, with the inscription “INOR” engraved on one side.

pharmachologic effect

The drug helps prevent pregnancy, causes effects in the body similar to the action of ovarian corpus luteum hormones, and also suppresses the effects caused by .

Pharmacodynamics and pharmacokinetics

What is Postinor?

Postinor is a remedy with a pronounced antiestrogenic And progestogenic activity. These properties of the drug complicate the process of conception at an early stage and help prevent pregnancy.

Pharmacodynamics

It is not known exactly how Postinor works. Contained in tablets levonorgestrel prevents ovulation and fertilization of the egg if UPC (unprotected sexual intercourse) occurs before ovulation (when the probability of fertilization is highest).

Levonorgestrel also causes changes in the endometrium, which make it difficult for a fertilized egg to penetrate the mucous layer of the uterine cavity. In cases where the attachment of the fertilized egg has already begun, the drug does not give the expected effect.

Wikipedia states that the mechanism of action levonorgestrel is implemented most successfully when the size of the dominant follicle is 17 mm. The drug best suppresses ovulation no later than three days before it.

Efficacy of tablets

The probability of pregnancy after using Postinor tablets is 15-42%. The effect after administration is better, the less time has passed after NPC.

If the drug was taken within 24 hours, its effectiveness is 95%, in the next 24 hours it decreases to 85%, on the third day - to 58%. There is no point in taking the drug later than 72 hours.

Is Postinor harmful?

Pharmacokinetics

Absorption in the digestive canal when taken orally is rapid and complete. In the body, the drug binds to SHBG and albumin: approximately 65% ​​of the dose taken is associated with SHBG, only 1.5% is in free form.

96 minutes after taking the tablet, plasma concentration levonorgestrel reaches 14.1 ng/ml. Then there is a 2-stage decrease in Cmax.

The drug is well distributed in tissues and organs.

Its biotransformation occurs in the liver. The resulting metabolic products (conjugated glucuronates) are pharmacologically inactive.

Levonorgestrel excreted from the body exclusively in the form of metabolic products. About half of the dose taken is excreted in the urine, the rest in feces. The value of the T1/2 indicator varies from 9 to 14.5 hours.

When Postinor is taken by a nursing woman, about 0.1% of the dose enters the body of an infant with milk.

Indications for use

“Emergency” contraception in case of failure of the chosen method of contraception or after NPC.

Contraindications

A contraindication to the use of the drug is intolerance levonorgestrel or any of the auxiliary ingredients contained therein.

The drug is used in pediatric practice. Data regarding its use in girls under 16 years of age are limited, therefore Postinor is not recommended for use in adolescence without medical supervision.

Side effects of Postinor: why is the drug dangerous?

In the annotation for the drug, the manufacturer reports that the most common reaction to the use of levonorgestrel is nausea .

In addition, the following side effects of Postinor were recorded during the studies:

• dizziness;
• headache;
• And vomit ;
• nausea;
• not related to the menstrual cycle ;
• disruption of the menstrual cycle (namely, a delay in menstruation after taking the pill for more than a week);
• increased fatigue.

Post-marketing observations have shown that sometimes (rather rarely) the use of the drug may be accompanied by: hypersensitivity reactions ( , the appearance of skin rashes, skin itching), , pain in the pelvic area and/or abdomen, swelling of the face.

Why is Postinor harmful?

Reviews of side effects allow us to conclude that, according to women, the most unpleasant phenomena after taking Postinor are:

• bleeding (in some reviews it is mentioned that, not knowing how to stop the bleeding after Postinor, the woman was forced to seek medical help);
• severe hormonal imbalance and severe cycle disorders (many cases have been described when, after taking Postinor, there are no periods for several cycles; for some, it takes up to a year to restore the regularity of menstruation).

This list can include the appearance of “male” characteristics, metabolic disorders And acne .

Sometimes the consequences of taking the Postinor tablet manifest themselves in the form of miscarriage of subsequent pregnancies and infertility.

To minimize harm to the body, the drug should be used no more than 3-4 times a year.

Postinor tablets: instructions for use

How to take Postinor?

The instructions for Postinor indicate that the contraceptive effect is ensured by taking two tablets (provided that the first tablet is taken in the first 3 days after NPC). A twelve-hour interval is maintained between doses 1 and 2.

If within 3 hours after taking the drug (regardless of whether 1 or 2 doses), you should immediately take another 750 mcg levonorgestrel (3rd tablet).

The product can be used in any phase of the menstrual cycle. A prerequisite is that the woman does not have a delay in menstruation.

After taking the pills, before the start of your next period, it is recommended to use barrier contraception (cervical cap or condoms).

Taking the drug is not a contraindication for continuing the use of hormonal agents for regular contraception.

How can you tell if the drug has worked?

The tablet begins to act immediately after dissolution and absorption in the intestinal tract.

Evidence that the drug has “worked” is menstruation.

Bleeding after use rules out pregnancy in approximately 95-85% of cases if it begins 3-6 days after taking the pill.

What might a delay after Postinor indicate?

If after using the drug there is no bleeding or bleeding begins later than the specified period, the woman is recommended to undergo a gynecological examination to rule out pregnancy.

You should consult a doctor not only if your period is late, but also if, after taking Postinor, the consequences are expressed in the form of bleeding that is unusually heavy for a woman. The causes of such bleeding may be exceeding the recommended dose and negative effects levonorgestrel on endometrium of the uterus .

Sometimes women note that they have brown discharge after taking it. The phenomenon is considered normal if the discharge appears within a few days, thus ending the menstruation artificially induced by the pills. However, for some women, spotting may continue for up to a month.

Most likely, this is an individual reaction to severe stress on the reproductive system, but only a doctor can accurately diagnose the cause of the discharge.

Causes for concern are menstrual bleeding lasting more than 14 days, lack of full periods, the appearance of clots or heavy brown discharge, and pain.

When should I get my period after taking the pill?

It is impossible to say exactly when your period will begin after using Postinor. The tablets contain a large amount levonorgestrel , so even a single use of the drug does not leave its mark on the body.

In most cases, after taking the drug, the menstrual cycle remains the same. Sometimes bleeding may begin earlier or slightly later. Normally, the delay should not be more than 5-7 days. Otherwise, pregnancy should be excluded.

After reception levonorgestrel A woman is advised to visit a doctor who will help her choose the most suitable method of regular contraception.

Is it worth taking Postinor if NPK occurs during menstruation?

Women with irregular cycles are more likely to become pregnant even during menstrual bleeding. The advisability of using “urgent” contraception if UPC occurred during menstruation can be determined by a doctor.

How often can you take Postinor?

To the question “How often can you take emergency contraceptive pills?” Doctors answer that drugs like Postinor are not intended for systematic use. They are used only in emergency situations and no more than 3-4 times a year.

Overdose

Clinical picture of overdose hormonal agents emergency contraception not described. Most likely, the first signs of poisoning will be nausea and breakthrough bleeding.

Postinor does not have a specific antidote.

Interaction

In combination with liver enzyme inducers, there is an increase in metabolism levonorgestrel .

The effectiveness of drugs that contain levonorgestrel , may be reduced when used simultaneously with:

• barbiturates ;
• preparations of St. John's wort (Hypericum perforatum);
• rafibutin ;
• ritonavir ;
• phenytoin ;

Women taking these drugs should consult their doctor before taking Postinor.

Levonorgestrel-containing drugs may cause increased toxicity , which is associated with a possible suppression of its metabolism.

Terms of sale

On prescription.

Storage conditions

Tablets should be stored at a temperature of 15-25°C.

Best before date

special instructions

“Emergency” contraception are intended for occasional use and do not replace a regular method of birth control.

“Emergency” contraception does not always prevent pregnancy. If there is doubt about the timing of NPC or if unprotected intercourse occurred more than 72 hours during the same cycle, the possibility that a fertilized egg has already implanted in the uterine wall cannot be ruled out.

In this regard, the use of tablets during the next sexual intercourse may be ineffective. If the cycle is delayed by more than 5 days, if atypical bleeding develops on the day of the expected menstruation, as well as if there are other reasons to suspect pregnancy, the fact of pregnancy should be excluded.

After reception levonorgestrel there is a risk of developing ectopic pregnancy . The absolute likelihood of this is low, since the drug interferes with ovulation and fertilization.

Ectopic pregnancy may persist despite the occurrence of uterine bleeding.

Most likely in women who have experienced fainting or severe abdominal pain, as well as a history of tubal surgery, , or PID .

Based on this, patients at risk are not recommended to take Postinor tablets.

Taking the pills may slightly change the pattern of bleeding, but in most cases the next menstruation begins a maximum of a week after the usual date.

If menstrual bleeding is delayed by more than 5 days, it is necessary to exclude the fact of pregnancy.

The drug should not be used by women with serious liver pathologies. The effectiveness of the tablets may be adversely affected by severe malabsorption (eg, granulomatous enteritis ).

For women suffering from similar diseases, before undergoing emergency contraception It is recommended to consult a doctor.

Postinor tablets contain lactose, which should be warned about in patients with lactase deficiency And disorders of glucose and galactose absorption .

The drug is ineffective as regular contraception and is not an alternative to it. It should also be remembered that this remedy does not replace the necessary precautions related to protection against STD .

If a woman applies for repeated use of Postinor, the doctor should recommend that she use long-term methods of birth control.

Research on Impact levonorgestrel The ability to drive a vehicle or operate machinery was not tested, but one should remember about the possibility of dizziness. levonorgestrel. Only in the first case its concentration is 1.5 mg/tablet, and in the second - 0.75 mg/tablet. That is Escapelle in the case of NPC, it should be taken once, and Postinor should be taken in 2 doses with an interval of 12 hours.

Which is better - Zhenale or Postinor?

Active substance Genale - synthetic antiprogestin . The substance is a derivative norethisterone and is used to terminate early pregnancy. Its content in each tablet is 10 mg.

Mifepristone is non-hormonal agent , which reversibly and transiently blocks exclusively peripheral PRs (receptors progesterone ). Depending on the phase of the menstrual cycle, the drug prevents the release of luteotropin , delays or blocks ovulation and causes disturbances in the transformation of the endometrium, which, in turn, complicates the implantation of the egg.

WHO data indicates that the use of low doses mifepristone more effective and safe than emergency contraception using levonorgestrel .

In addition, it has been experimentally proven that the contraceptive effect mifepristone does not decrease with increasing interval between NPC and administration Genale up to 120 hours. This is also a significant advantage of the latter over Postinor.

If necessary “urgent” contraception it is enough to take 1 tablet during the first 72 hours Genale . The drug is used 2 hours before meals.

What is better - Postinor or Ginepristone?

Active substance Gynepristone is also mifepristone at a concentration of 10 mg/tablet. Thus, the drug has the same advantages over Postinor as Genale .

The drug is highly effective, characterized by the absence of significant side effects and can be used for occasional contraception in women with irregular sex life.

In addition, the drug is more affordable compared to Postinor. Its price in Russian pharmacies is approximately 100-120 rubles lower than the price of Postinor.

Postinor and alcohol

Is it possible to combine Postinor tablets with alcohol? There are no recommendations in this regard in the manufacturer's instructions.

However, it should be remembered that alcohol is not compatible with the vast majority of pharmaceutical products.

Drinking alcoholic beverages in combination with Postinor can cause a sharp dilation, and then an equally sharp constriction of blood vessels, which in turn will complicate the woman’s condition when the drug provokes rejection of the uterine mucosa.

In addition, alcohol increases the level of liver enzymes, thereby speeding up metabolism. And since biotransformation levonorgestrel is carried out in the liver, the contraceptive effect of Postinor while drinking alcohol can be very questionable.

Postinor is a one-time use emergency contraceptive drug. Reviews and possible consequences are the most common reason for not using it. The maximum effectiveness of the drug is 95%, provided that it was taken in the first 24 hours. It has a powerful contraceptive, antiestrogenic and gestagenic effect on the body. Dispensed by prescription.

The drug is available in tablet form. Levonorgestrel is an active substance that is an artificial gestagen (an analogue of progesterone, only synthetic).

The composition contains as additional substances:

• corn and potato starch;
• talc;
• magnesium stearate;
• silicon dioxide;
• lactose monohydrate.

Pharmacodynamics

Typically, taking Postinor does not affect the monthly cycle, namely, it does not change its duration and the nature of the discharge. However, sudden occurrence of bleeding between menstruation and a slight (5-7 days) delay are allowed.

Efficiency of 95% is achieved when taking the tablet immediately. If a lot of time has passed since coitus, the effectiveness of the drug will be reduced. Also, the drug will be useless if the egg has already been implanted.

Pharmacokinetics

The drug, almost in full, quickly enters the bloodstream, reaching its maximum concentration after 1.5 hours. Then the content of the active substance begins to decrease and after 26 hours the half-life begins. Excretion is carried out through the genitourinary system and intestines.

Indications for taking the drug

Postinor (reviews and consequences vary depending on the woman’s health) is used when there is a need for emergency contraception (unprotected coitus, unreliability of the contraceptive method used). The effectiveness depends on the time during which it was taken.

It is advisable that this be the first 24 hours after unprotected sexual contact.

The later the pill is taken, the less effective it will be. If the implantation of the egg has already taken place, then there is no point in taking it. Also plays a role in what period of the cycle sexual intercourse took place - if before ovulation, that is, when the chances of getting pregnant are highest, then the drug will have an effect.

Contraindications

Postinor is not prescribed if:

• there are allergic reactions to one of the components of the drug;
• the patient has not reached 16 years of age;
• during pregnancy;
• while breastfeeding. If the drug still needs to be taken, then lactation should be stopped for a day after taking the pills;
• in the presence of severe liver diseases;
• in case of lactose intolerance (the composition contains lactose monohydrate);
• if you have Crohn's disease;
• if you have problems with the gastrointestinal tract;
• for liver diseases;
• if the patient had jaundice.

Instructions for use, dosage of the drug

To achieve the desired effect, just two tablets taken strictly according to the instructions are enough. Within 12-72 hours one and after 12 hours the second. If vomiting occurs in the first three hours after taking it, you need to take the pill again.

Postinor (reviews and consequences indicate that the drug can be taken on any day, regardless of the cycle) is indicated for use only after preliminary exclusion of possible pregnancy (which is quite possible if menstruation is irregular), but not more than once during the cycle. Otherwise, the risk of spotting and bleeding increases.

Until the onset of menstruation, it is necessary to resort to the use of barrier contraceptives, for example, a condom or a cervical cap. It is not recommended to take this drug simultaneously with drugs that promote the induction of enzymes in the liver, since in this case the metabolism of the active substance is accelerated.

For example, topiromate, amprenavir, tretinoin, lansoprazole, as well as drugs containing ampicillin, tetracycline, rifabutin and barbiturates, significantly reduce the effectiveness of Postinor.

This drug affects the concentration of active substances in the blood, changing it, and accordingly the effectiveness of drugs aimed at correcting blood sugar, anticoagulants and glucocorticosteroids. There is a risk of increased toxicity of cyclosporine due to suppression of metabolic processes when taking medications containing levonorgestrel.

Reasons for the ineffectiveness of the drug

There are only two reasons why the drug was ineffective and an unwanted pregnancy occurred:

• the pills were taken too late;
• The pills were taken when fertilization had already occurred.

Is it possible to take 2 tablets at the same time?

This depends on the amount of time that has passed since sexual intercourse. If 2-3 hours, then it is better to take the tablets separately, as indicated in the instructions. If more than 10 hours have passed or you are not sure that it will be possible to take the second tablet on time, then you can take two at once.

How does abortion occur after taking the drug?

The mechanism of action is as follows: when entering the body, the active substances of the drug help suppress ovulation and cause changes in the endometrium of the uterus, preventing the implantation of the egg and its removal from the body through the appearance of heavy bleeding.

When should my period start after taking the pill?

Ideally, if there is no hormonal imbalance after taking the pills, then your period should come as scheduled.

However, this situation is more the exception than the rule, and in most cases the cycle still goes astray (either in one direction or the other). But it is impossible to say exactly when the critical days will begin, so the woman can only wait.

How to understand that the drug has worked

What happens if you don't follow the instructions?

Failure to follow the instructions is fraught with both mild and very serious consequences. Their severity directly depends on the general health of the woman.

Side effects prescribed in the instructions

Side effects may include:

• nausea;
• pain in the lower abdomen;
• menstrual irregularities (delayed menstruation);
• vomit;
• diarrhea;
• dizziness and headache;
• bloody vaginal discharge not associated with menstruation;
• problem with the vascular system (increased blood clotting and blood clots);
• allergic reactions (swelling, rash, urticaria, itching).

How to deal with the consequences of taking Postinor

If the instructions for taking the drug were followed, then no significant consequences for the reproductive and reproductive systems usually occur. If you have problems with the circulatory system, this drug is not recommended for use, but if you do take it, you need to regularly have your blood tested to determine the degree of clotting.

An increase in this indicator is fraught with the formation of blood clots, which over time clog blood vessels, which leads to deterioration of blood flow to organs and tissues and, as a result, a stroke, and in the worst case, instant death.

If the examination shows excessive blood thickening, you should immediately contact a specialized specialist who will prescribe blood thinning medications. Postinor (reviews and consequences for those who have serious health problems can be severe) is prohibited for use if you have liver problems.

If admission cannot be avoided, the patient should be prepared for a deterioration of the condition and exacerbation of the disease.

In case of severe overdose of the drug and the appearance of severe side effects, gastric lavage is recommended. If the dose is exceeded slightly, but there are pronounced side effects, then symptomatic treatment is prescribed, because There is no antidote for this drug.

What should I do if bleeding starts after taking the pills?

Sometimes women are faced with a situation where bleeding begins after taking emergency contraception. However, not every case is dangerous. Often the first menstruation is stronger and more abundant than usual.

Up to 80 ml is considered normal. discharge for the entire period of menstruation. A larger volume of discharge may be associated with an imbalance in hormones. This is a temporary phenomenon, everything will return to normal in about a month. You should pay attention to the duration of bleeding. It is acceptable when the duration of critical days increases by 2-3 days.

If by 5-6 days the bleeding becomes weaker and does not cause discomfort, then there is no reason to worry. If the discharge is as strong and abundant by day 6-7, then you need to urgently seek medical help. If bleeding lasts more than 10 days, then, regardless of whether it is severe or not, you need to consult a doctor.

First aid

The priority, in case of bleeding, is to visit a gynecologist.

Before the ambulance arrives, the following measures should be taken:

• lie down with your legs above the level of your heart, and place a heating pad or plastic bottle with cold water on your stomach.
• take a blood-stopping drug;
• Drinking plenty of fluids is also recommended.

When is it necessary to call an ambulance?

Calling an ambulance is necessary in the following cases:

• gaskets are changed once an hour or more often;
• gaskets are changed even at night;
• bleeding does not stop for more than 24 days;
• bleeding is so severe that it prevents you from doing normal things, such as going to work or going to the gym;
• there are clots in the blood;
• shortness of breath, lethargy, drowsiness appeared - the first signs of anemia.

Alcohol compatibility

The manufacturer did not provide any data regarding the compatibility of this drug with alcohol. However, a woman who cares about her health already understands that not only Postinor, but also any other medicine is incompatible with alcoholic beverages.

Of course, a glass of champagne and a glass of beer won’t do much harm, but if you drink something stronger and in large quantities, the negative consequences will not take long to appear. You should also take into account the woman’s general condition and the presence of liver problems, in particular.

The active ingredient of the drug, like alcohol, is excreted by the liver, so before taking two substances at the same time, you should think carefully about whether the organ needs such a double load. Alcohol significantly increases the amount of enzymes in the liver and other important active substances.

The result is an acceleration of metabolism, which entails premature aging of the organ.

It should also be taken into account that accelerated metabolism leads to faster biotransformation of the active substance of the drug and is eliminated from the body faster. The result is a decrease in its effectiveness. That is, the body is exposed to a large dose of hormones, but due to rapid elimination from the body, they do not have the desired effect.

Side effects from taking the drug with alcohol:

• Postinor and alcohol alone cause vomiting.